Alpha GPC

In short: 

  • cognition enhancement
  • increase power output via skeletal muscle contraction
  • prevent cognitive decline

Alpha-glycerophosphocholine (alpha-GPC) is a cholinergic compound that is used for cognitive-enhancement and to increase power output in athletes. It appears to also support cellular membranes, and may help prevent cognitive decline.

When ingested, alpha-GPC is metabolized into choline and glycerol-1-phosphate. Choline is a precursor of acetylcholine, a neurotransmitter involved in memory, attention, and skeletal muscle contraction.

Acetylcholine is also responsible for the action potential that stimulates muscles to contract. Therefore, it’s theorized that increased acetylcholine levels lead to a stronger signal for muscle contraction and, consequently, increased force production.


studies have used a dosage of 300–600 mg, supplemented 30–60 minutes prior to exercise.

"Alpha-GPC,", published on 16 July 2013, last updated on 15 March 2022,